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Lack of cardio is the biggest cause and not just founders but even singers (KK) and models/actors (Siddharth Shukla) have died because of it. Even Nitin Kamath (Zerodha) sufferer a heart attack thought he recovered. All of the above habitually went to gym but still got heart attack. Only way to maintain cardiovascular health is to play sports or go for running which people stop doing as they become adult (studies or job).